Study: CBD Could Prevent Haloperidol-Induced Orofacial Dyskinesia

Cannabidiol (CBD) may prevent haloperidol-induced orofacial dyskinesia, according  to new research being published by the journal Brain, Behavior, and Immunity; the research was epublished by the National Institute of Health.

“The chronic use of drugs that reduce the dopaminergic neurotransmission can cause a hyperkinetic movement disorder called tardive dyskinesia (TD)”, states the study’s abstract. “The pathophysiology of this disorder is not entirely understood but could involve oxidative and neuroinflammatory mechanisms. Cannabidiol (CBD), the major non-psychotomimetic compound present in Cannabis sativa plant, could be a possible therapeutic alternative for TD.”

The study states that “This phytocannabinoid shows antioxidant, anti-inflammatory and antipsychotic properties and decreases the acute motor effects of classical antipsychotics. The present study investigated if CBD would attenuate orofacial dyskinesia, oxidative stress and inflammatory changes induced by chronic administration of haloperidol in mice.”

Furthermore, researchers “verified in vivo and in vitro (in primary microglial culture) whether these effects would be mediated by PPARγ receptors. The results showed that the male Swiss mice treated daily for 21 days with haloperidol develop orofacial dyskinesia. Daily CBD administration before each haloperidol injection prevented this effect.”

Mice treated with haloperidol “showed an increase in microglial activation and inflammatory mediators in the striatum. These changes were also reduced by

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Seattle Court Agrees to Expunge Past Marijuana Convictions

Judges in Seattle have agreed to clear past misdemeanor convictions for marijuana possession that were prosecuted before marijuana was legalized in Washington, reports the Seattle Times.

All seven judges of the Seattle Municipal Court have signed an order setting out a process for vacating the cases. The ruling follows City Attorney Pete Holmes’ filing of a motion in April asking the court to vacate the convictions.

In his motion, Holmes argued that possessing small amounts of marijuana is no longer illegal and clearing past convictions would right the injustices of a drug war that targeted people of color.

About 542 people could be affected. The ruling covers from about 1996 – when municipal courts, rather than county district courts, began handling those misdemeanors – to 2010 when Holmes became city attorney and stopped prosecuting low-level, non-violent marijuana cases.

“Insomuch as the conduct for which the defendant was convicted is no longer criminal, setting aside the conviction and dismissing the case serves the interests of justice,” wrote the judges in their ruling.

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Epileptic 5-Year-Old May Now Bring Cannabis-Based Medicine to School

Although the use of cannabis-derived drugs has seen an uptick in usage over the past two years, children in need of the medication have faced their fair share of roadblocks. One particular concern has been the ability (or inability) of some students prescribed with cannabis-based medications to bring their treatments into school. However, with a new case in California, the tide may have somewhat shifted: an epileptic 5-year-old may now bring cannabis-based medicine to school.

Another Win for Cannabis: Epileptic 5-Year-Old May Now Bring Cannabis-Based Medicine to School

Brooke Adams, a five-year-old girl attending kindergarten at Village Elementary School in the Santa Rosa area, received good news on Friday: her school will now allow the young medical cannabis patient bring her seizure medication to school without question.

The Rincon Valley Union School District had previously disallowed Adams to bring her cannabis ointments to school because it contained THC—the psychoactive component in cannabis. Under both state and federal law, bringing any form of marijuana on school grounds is strictly forbidden.

However, state administrative law Judge Charles Marson made an exception for the girl, because of the volatile nature of the seizures she sustains.

According to her mother, Jana Adams, Brooke’s seizures are often random, increasing the need for

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Maine Restaurant Sedating Lobsters With Cannabis Under Investigation

A Maine restaurant that had been sedating lobsters with cannabis before boiling them alive is now under investigation for the culinary preparation, according to media reports. Charlotte Gill, the owner of Charlotte’s Legendary Lobster Pound in Southwest Harbor, Maine, had been offering the option to patrons ordering live Maine lobster at the restaurant.

But state regulators have taken notice and now the Maine Health Inspection Program is investigating the practice, a spokesperson for the Department of Health and Human Services has confirmed.

Gill is a registered medical marijuana caregiver and grows the cannabis she uses for the lobster. But a spokesman for the Maine Medical Marijuana program, David Heidrich, said in an email that the use of cannabis was not appropriate.

“Medical marijuana may only be grown for and provided to persons with a marijuana recommendation from a qualified medical provider,” he said. “Lobsters are not people.”

Temporarily Off the Menu

The restaurant has temporarily stopped selling the “high-end lobster,” as Gill calls it, but she hopes to be able to offer it again.

“After being contacted by the state, and upon reviewing its present laws and codes applicable to this arena, and then making a few minor adjustments to our procedure, we are

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New Study Provides Evidence Supporting the Use of Cannabinoids to Treat Prostate Cancer

Cannabinoids may provide a potential treatment option for prostate cancer, according to a new study published by the journal The Prostate.

“Cannabinoids have demonstrated anticarcinogenic properties in a variety of malignancies, including in prostate cancer”, states researchers. In the present study, they “explored the anti-cancer effects of the synthetic cannabinoid WIN 55,212-2 (WIN) in prostate cancer.”

For the study, “Established prostate cancer cells (PC3, DU145, LNCaP) were treated with varying concentrations of WIN”, and “Cell proliferation was determined by the MTS assay.” The anti-migration and anti-invasive potential of WIN “was examined by the wound healing assay and the matrigel invasion assay.” Cell cycle analysis was performed by flow cytometry, and mechanistic studies were performed by Western blot.

Animals were randomized into two groups: saline control and WIN (5 mg/kg), delivered by intraperitoneal injection three times per week for 3 weeks.

“WIN significantly reduced prostate cancer cell proliferation, migration, invasion, induced apoptosis, and arrested cells in Go/G1 phase in a dose-dependent manner”, claim researchers.

They conclude; “The following study provides evidence supporting the use of WIN as a novel therapeutic for prostate cancer.”

For more info on this study, click here.

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